物理学科Seminar 第164讲
暨纳微能源研究所Seminar第17讲
题目：Multiplexed Resistive Pulse Sensors for Biomedical Research and Health Care (用于生物医学和健康照顾的复式电阻脉冲传感器）
报告人：Prof. Jiang Zhe (The Universiy of Akron, Ohio, USA)
时间：2013年7月2日（周二)10:30
地点：校本部E301
主办部门：理学院物理系
Abstract：
The development of portable and inexpensive lab-on-a-chip devices that are able to rapidly detect and quantify important biological particles, including bacteria, tumor cells, viruses, DNA, and biomarkers, will help to fill an urgent and critical need for public health monitoring, and will further biomedical research. One of the most important challenges that must be met for lab-on-a-chip devices to move from laboratory into field applications is the development of high density parallel sensing arrays that can process relatively large volumes of sample in a reasonable time. I will present e an on-chip multiplexed multichannel resistive pulse sensor for high throughput detection and counting of micro-/nano- scale particles. The high throughput results from using multiple parallel microfluidic channels to analyze the sample. Detection is achieved by using bio-inspired frequency division multiplexing; each microchannel is modulated with its own known and unique frequency, a combined measurement is made across a single pair of electrodes, and the measured signal is demodulated to determine the signal across each individual channel. Testing results using 30µm polystyrene particles demonstrate that the throughput of the multiplexed device is improved 300% over a single channel device; this is achieved by simultaneously detecting particles through the device’s four parallel channels. The multiplexed detection principle can be extended to a larger number of channels to further improve the throughput, without increasing the external detection electronics. Finally I will present my current research of using the multiplexed resistive pulse sensor platform to detect protein biomarkers and circuiting tumor cells in blood for early cancer diagnosis and prognosis. A brief introduction of my other on-going research projects will also be presented.
